AutoCAD

Center the Plot changes position, not scale. Use it after the correct device, paper, plot area and scale have already been chosen.

Physical output adds the operating-system driver, queue, loaded media and hardware printable area after the CAD setup. Test the device outside AutoCAD first.

Your first AutoCAD print is easier if you ignore most advanced options and make one correct PDF from one Layout first.

Plot Offset controls where the selected plot area sits on the printable page. It should be adjusted only after paper, area and scale are correct.

One Layout should be simple: activate the correct sheet, confirm its named Page Setup, Preview, then output.

AutoCAD still says Plot, but for normal CAD output print and plot are essentially the same process. The destination can be PDF, a desktop printer or a large-format plotter.

A sideways sheet is usually an output setting problem, not a reason to rotate the drawing. Set the paper first, then choose Portrait or Landscape.

To print only part of a drawing, use Plot Area = Window and pick two corners. This is an area selection, not the same thing as selecting AutoCAD objects.

The Plot dialog looks crowded because it contains device, paper, area, scale, position and graphic settings in one place. You only need to learn them in a sensible order.